A dangerous drug interaction could occur, leading to serious side effects.

You may have thoughts about suicide when you first start taking an antidepressant such as Cymbalta, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Avoid drinking alcohol. It may increase your risk of liver damage. Cymbalta may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Before taking Cymbalta

Do not use Cymbalta together with thioridazine (Mellaril), or an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate). A dangerous drug interaction could occur, leading to serious side effects. You must wait at least 14 days after stopping an MAO inhibitor before you can take Cymbalta. After you stop taking Cymbalta, you must wait at least 5 days before you start taking an MAOI. Do not use Cymbalta if you are allergic to duloxetine, or if you have untreated or uncontrolled glaucoma.

To make sure you can safely take Cymbalta, tell your doctor if you have any of these other conditions:

* liver or kidney disease;
*seizures or epilepsy;
*a bleeding or blood clotting disorder;
*glaucoma;
You should not breast-feed while taking Cymbalta.

Older adults may be more sensitive to the side effects of this medication.

Do not give Cymbalta to anyone younger than 18 years old without the advice of a doctor.
How should I take Cymbalta?

Take Cymbalta exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.

Try to take Cymbalta at the same time each day. Follow the directions on your prescription label.

Do not crush, chew, break, or open a delayed-release capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time. It may take 4 weeks or longer before your symptoms improve. Keep using the medication as directed. Do not stop using Cymbalta without first talking to your doctor. You may have unpleasant side effects if you stop taking this medication suddenly.

Store Cymbalta at room temperature away from moisture and heat.

See also: Cymbalta dosage (in more detail)
What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include agitation, hallucinations, fever, overactive reflexes, loss of coordination, extreme drowsiness, vomiting, diarrhea, seizure (convulsions), fast heart rate, feeling light-headed, or fainting.
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